Journal
WORLD JOURNAL OF GASTROENTEROLOGY
Volume 23, Issue 10, Pages 1780-1786Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v23.i10.1780
Keywords
Colorectal cancer; Interleukin-6; Invasion depth; Lymph node metastases
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Funding
- National Natural Science Foundation of China [81502131]
- Natural Science Foundation of Chongqing [cstc2016jcyjA0405]
- Scientific and Technological Research Program of Chongqing Municipal Education Commission [KJ1500332]
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AIM To compare the expression levels of interleukin (IL)-6 in colorectal cancer (CRC) tissues and adjacent non-cancerous tissues, and analyse the correlation of IL-6 expression with the clinicopathological parameters of CRC. METHODS Fifty CRC tissue specimens and 50 matched adjacent mucosa specimens were collected. The expression of IL-6 in these clinical samples was examined by immunohistochemical staining. The correlation between IL-6 expression and clinicopathological parameters was assessed by statistical analysis. RESULTS IL-6 expression was significantly elevated in CRC tissues compared with noncancerous tissues (P < 0.001). IL-6 expression was positively correlated with tumour TNM stage (P < 0.001), but a negative correlation was detected between IL-6 expression and tumor histological differentiation in CRC (P < 0.05). Furthermore, IL-6 expression was associated with invasion depth and lymph node metastasis in CRC. CONCLUSION IL-6 might be a useful marker for predicting a poor prognosis in patients with CRC and might be used as a potential therapeutic target in CRC.
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