Journal
INFECTION AND IMMUNITY
Volume 85, Issue 10, Pages -Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.00350-17
Keywords
caspase-11; caspase-1; inflammasome; A. baumannii
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Activation of caspase-11 by some Gram-negative bacteria triggers the caspase-1/interleukin 1 beta (IL-1 beta) pathway, independent of canonical inflammasomes. Acinetobacter baumannii is a Gram-negative, conditionally pathogenic bacterium that can cause severe pulmonary infection in hospitalized patients. A. baumannii was revealed to activate canonical and noncanonical inflammasome pathways in bone marrow-derived macrophages (BMDMs). Pulmonary infection of caspase-11(-/-) mice with A. baumannii showed that caspase-11 deficiency impaired A. baumannii clearance, exacerbated pulmonary pathological changes, and enhanced susceptibility to A. baumannii. These data indicate that the caspase-11-mediated innate immune response plays a crucial role in defending against A. baumannii.
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