Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 46, Issue -, Pages 170-178Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2017.07.009
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Funding
- National Natural Science Foundation of China [8141101062, 31471219, 31630095]
- Center of Life Sciences at Tsinghua University
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Pervasive transcription in mammalian genomes produces thousands of long noncoding RNA (lncRNA) transcripts. Although they have been implicated in diverse biological processes, the functional relevance of most lncRNAs remains unknown. Recent studies reveal the prevalence of lncRNA-mediated cis regulation on nearby transcription. In this review, we summarize cis- and trans-acting lncRNAs involved in stem cell pluripotency and reprogramming, highlighting the role of regulatory lncRNAs in providing an additional layer of complexity to the regulation of genes that govern cell fate during development.
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