Journal
WORLD JOURNAL OF GASTROENTEROLOGY
Volume 23, Issue 19, Pages 3565-3568Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v23.i19.3565
Keywords
Fecal microbiota transplantation; Epilepsy; Crohn's disease; Gut microbiota; Brain-gut axis
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Funding
- Public Donated Grant Intestine Initiative
- National Nature Science Foundation of China [81670495]
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Fecal microbiota transplantation (FMT) is a promising strategy that involves reconstruction of gut microbiota. Recently, it has been considered as a treatment of Crohn's disease (CD) and certain neurological diseases. Here, to the best of our knowledge, we report the first case that used FMT to achieve remission of intestinal and neurological symptoms in a girl with CD and a 17-year history of epilepsy. During the 20 mo of follow-up, FMT has proved its efficacy in preventing relapse of seizures after withdrawing the antiepileptic drugs. Furthermore, this finding highlights the role of microbiota-gut-brain axis and inspires a novel treatment for epilepsy through remodeling gut microbiota.
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