Journal
AICHE JOURNAL
Volume 63, Issue 10, Pages 4694-4704Publisher
WILEY
DOI: 10.1002/aic.15807
Keywords
hydrodynamics; micropacked bed; pressure drop; liquid holdup; multiphase flow model; fixed beds
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Funding
- office of China Postdoctoral Council (The International Postdoctoral Exchange Fellowship) [20150020]
- Novartis-MIT Centre for Continuous Manufacturing
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Hydrodynamics of gas-liquid two-phase flow in micropacked beds are studied with a new experimental setup. The pressure drop, residence time distribution, and liquid holdup are measured with gas and liquid flow rates varying from 4 to 14 sccm and 0.1 to 1 mL/min, respectively. Key parameters are identified to control the experimentally observed hydrodynamics, including transient start-up procedure, gas and liquid superficial velocities, particle and packed bed diameters, and physical properties of the liquids. Contrary to conventional large packed beds, our results demonstrate that in these microsystems, capillary forces have a large effect on pressure drop and liquid holdup, while gravity can be neglected. A mathematical model describes the hydrodynamics in the micropacked beds by considering the contribution of capillary forces, and its predictions are in good agreement with experimental data. (c) 2017 American Institute of Chemical Engineers AIChE J, 63: 4694-4704, 2017
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