Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 56, Issue 41, Pages 12727-12731Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201707181
Keywords
copper; cyclobutanone; olefination; oximes; radicals
Categories
Funding
- NSF of China [2167020084]
- NSF of Jiangsu Province [BK20140594]
- 1000-Youth Talents Plan
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The first example of intermolecular olefination of cyclobutanone oximes with alkenes via selective C-C bond cleavage leading to the synthesis of nitriles in the presence of a cheap copper catalyst is reported. The procedure is distinguished by mild and safe reaction conditions that avoid ligand, oxidant, base, or toxic cyanide salt. A wide scope of cyclobutanones and olefin coupling components can be used without compromising efficiency and scalability. The alternative visible-light-driven photoredox process for this coupling reaction was also uncovered.
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