4.8 Article

Gold-Triggered Uncaging Chemistry in Living Systems

Journal

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 56, Issue 41, Pages 12548-12552

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201705609

Keywords

bioorthogonal; fluorescent probes; gold; heterogeneous catalysis; prodrugs

Funding

  1. EPSRC [EP/N021134/1]
  2. CRUK
  3. Royal Society [RG150377]
  4. EC (ChemoBOOM) [H2020-MSCA-IF-2014-658833]
  5. CMVM of the University of Edinburgh
  6. CIBER-BBN
  7. VI National RDi Plan
  8. Instituto de Salud Carlos III
  9. University of Zaragoza [JIUZ-2016-TEC-13]
  10. ERC under the EU's [340163]
  11. EPSRC [EP/N021134/1] Funding Source: UKRI
  12. Cancer Research UK [17494] Funding Source: researchfish
  13. Engineering and Physical Sciences Research Council [EP/N021134/1] Funding Source: researchfish

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Recent advances in bioorthogonal catalysis are increasing the capacity of researchers to manipulate the fate of molecules in complex biological systems. A bioorthogonal uncaging strategy is presented, which is triggered by heterogeneous gold catalysis and facilitates the activation of a structurally diverse range of therapeutics in cancer cell culture. Furthermore, this solid-supported catalytic system enabled locally controlled release of a fluorescent dye into the brain of a zebrafish for the first time, offering a novel way to modulate the activity of bioorthogonal reagents in the most fragile and complex organs.

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