Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 56, Issue 41, Pages 12668-12671Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201705048
Keywords
helical molecules; ion selectivity; potassium binding; potassium transport; synthetic channels
Categories
Funding
- Natural Science Foundation of China [21574054, 21274051, 21420102007, 21574056, 91527302]
Ask authors/readers for more resources
Potassium ion channels specifically transport K+ ions over Na+ ions across a cell membrane. A queue of four binding sites in the K+ channel pore plays significant roles during highly selective conduction. A kind of aromatic helical oligomer was synthesized that can selectively bind K+ over Na+. By aromatic stacking of helical oligomers, a type of artificial K+ channels with contiguous K+ binding sites was constructed. Such artificial channels exhibited exceptionally high K+/Na+ selectivity ratios during transmembrane ion conduction.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available