Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 9, Issue 39, Pages 34185-34193Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.7b05294
Keywords
layered double hydroxides; nanosheets; nanomaterials; anticancer therapy; drug delivery
Funding
- National Natural Science Foundation of China [51173124]
- National Basic Research Program of China [2012CB932400, 2011CB808400]
- School of Engineering of University of Edinburgh
- Royal Society Research Grant Scheme [RG150564]
- Chengdu University [2081916010, ARRLKF16-05]
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Layered double hydroxide (LDH) nanoparticles have been widely used for various biomedical applications. However, because of the difficulty of surface functionalization bf LDH nanoparticles, the systemic administration of these nanomaterials for iii vivo therapy remains a bottleneck. In this work, we develop a novel type of aqueous dispersible two-dimensional ultrathin LDH nanosheets with a size of about 50 nm and a thickness of about 1.4 to 4 nm. We are able to covalently attach positively charged rhodamine B fluorescent molecules to the nanosheets, and the, nanohybrid retains strong fluorescence in liquid and even dry powder form Therefore, it is available for bioimaging. Beyond this, it is convenient to modify the nanosheets with neutral poly(ethylene glycol) (PEG), so the nanohybrid is suitable for drug delivery through systemic administration. Indeed, in the test of using these nanostructures for delivery of a negatively charged anticancer drug, methotrexate (MTX), in a mouse model, dramatically improved therapeutic efficacy is achieved, indicated by the effective inhibition of tumor growth. Furthermore, our systematic in vivo safety investigation including measuring body weight, determining biodistribution in major organs, hematology analysis, blood-biochemical assay, arid hematoxylin and eosin stain demonstrates that the new material is biocompatible. Overall, this work represents a major development in the path of modifying functional LDH nanomaterials for clinical applications.
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