Journal
ADVANCED MATERIALS
Volume 29, Issue 37, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201703156
Keywords
biomaterials; hydrogels; photodegradation; tissue engineering; vascular engineering
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Funding
- University of Washington Faculty Startup Grant
- National Science Foundation CAREER Award [DMR 1652141]
- University of Washington Bioengineering Cardiovascular Training Grant (Institutional National Research Service Award) [T32EB001650]
- National Institutes of Health [1F30HL134298, DP2DK102258]
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A photodegradable material-based approach to generate endothelialized 3D vascular networks within cell-laden hydrogel biomaterials is introduced. Exploiting multiphoton lithography, microchannel networks spanning nearly all size scales of native human vasculature are readily generated with unprecedented user-defined 4D control. Intraluminal channel architectures of synthetic vessels are fully customizable, providing new opportunities for next-generation microfluidics and directed cell function.
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