Journal
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
Volume 13, Issue -, Pages 2087-2093Publisher
BEILSTEIN-INSTITUT
DOI: 10.3762/bjoc.13.206
Keywords
ball-mill; green chemistry; mechanochemistry; peptide synthesis; SPPS
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Funding
- Centre National de la Recherche Scientifique (CNRS)
- University of Montpellier
- LabEx CheMISyst (through ANR programme) [ANR-10-LABX-05-01]
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While presenting particularly interesting advantages, peptide synthesis by ball-milling was never compared to the two traditional strategies, namely peptide syntheses in solution and on solid support (solid-phase peptide synthesis, SPPS). In this study, the challenging VVIA tetrapeptide was synthesized by ball-milling, in solution, and on solid support. The three strategies were then compared in terms of yield, purity, reaction time and environmental impact. The results obtained enabled to draw some strengths and weaknesses of each strategy, and to foresee what will have to be implemented to build more efficient and sustainable peptide syntheses in the near future.
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