Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 56, Issue 42, Pages 12997-13000Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201707187
Keywords
amperometry; nanoelectrodes; phagolysosomes; reactive oxygen species; reactive nitrogen species
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Funding
- National Natural Science Foundation of China [21375099, 21675121]
- State Key Laboratory of Electroanalytical Chemistry [SKLEAC201706]
- State Key Laboratory of Physical Chemistry of Solid Surfaces (PCOSS, University of Xiamen, China) through a Distinguished Scientist Chair
- PSL
- Ecole Normale Superieure
- CNRS
- University Pierre and Marie Curie [UMR 8640]
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Nanoelectrodes allow precise and quantitative measurements of important biological processes at the single living-cell level in real time. Cylindrical nanowire electrodes (NWEs) required for intracellular measurements create a great challenge for achieving excellent electrochemical and mechanical performances. Herein, we present a facile and robust solution to this problem based on a unique SiC-core-shell design to produce cylindrical NWEs with superior mechanical toughness provided by the SiC nano-core and an excellent electrochemical performance provided by the ultrathin carbon shell that can be used as such or platinized. The use of such NWEs for biological applications is illustrated by the first quantitative measurements of ROS/RNS in individual phagolysosomes of living macrophages. As the shell material can be varied to meet any specific detection purpose, this work opens up new opportunities to monitor quantitatively biological functions occurring inside cells and their organelles.
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