Journal
CHEMMEDCHEM
Volume 12, Issue 19, Pages 1610-1615Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cmdc.201700370
Keywords
antibiotics; hybrid lipopeptides; membrane disruption; microbial resistance; mode of action
Categories
Funding
- Department of Science and Technology
- Council of Scientific and Industrial Research (CSIR), Government of India
- University Grants Commission (UGC)
Ask authors/readers for more resources
Herein we report the potent antimicrobial activity of alpha,gamma-hybrid lipopeptides composed of 1:1 alternating - and gamma-amino acids. Along with their potent antimicrobial activity against various Gram-positive and Gram-negative bacteria, these hybrid lipopeptides were found to be less hemolytic. Studies into the mechanism of action revealed that these short cationic lipopeptides bind and disrupt the bacterial cell membrane. Time-kill kinetics analyses revealed that the potent alpha,gamma-hybrid lipopeptides completely inhibit bacterial growth in less than 20 minutes. Overall, the promising antimicrobial activity along with lower hemolytic activity displayed by these alpha,gamma-hybrid lipopeptides make them well suited for further exploration into the design of potent lipopeptide antibiotics.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available