Journal
DALTON TRANSACTIONS
Volume 46, Issue 38, Pages 12785-12789Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7dt02789c
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Funding
- Leverhulme Early Career Fellowship [ECF-2014-178]
- King's College London GTS-PhD Studentship
- Faculty Graduate School International Studentship, respectively
- National Natural Science Foundation of China [21401078]
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Tetranuclear copper(II) complexes containing multiple diclofenac and Schiff base moieties, 1-4, are shown to kill bulk cancer cells and cancer stem cells (CSCs) with low micromolar potency. The most effective complex, 1, elicits its cytotoxic effect by elevating the intracellular reactive oxygen species (ROS) levels and inhibiting cyclooxygenase-2 (COX-2) expression.
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