Journal
CARBOHYDRATE POLYMERS
Volume 174, Issue -, Pages 13-24Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2017.06.013
Keywords
Triple helical beta-(1 -> 3)-glucan; Self-assembly; Tetraphenylethylene; Blue fluorescence; Lentinus edodesa
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Funding
- National Key Research and Development Program of China [2016YFD0400202]
- National Natural Science Foundation of China [21574102, 21274114, 21334005]
- New Century Excellent Talents Program of Education Ministry [NCET-13-0442]
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We report a unique self-assembly of lentinan, a triple helical beta-(1 -> 3)-glucan (t-LNT), in water. By molecular dynamics simulation, it was found that t-LNT aggregated preferentially along the chain direction to form long chains, accompanied by side-direction linkage to form branches. Transmission electron microscopy images demonstrated that t-LNT formed dendrite-like fibers, which further formed fishnet-like porous/mesoporous aggregates with increasing concentration. The meshes in the fishnet were ascribed to the intersection of branches. The major driving force for aggregation was expected to be hydrogen bonding between hydroxyl groups in t-LNT chains. Based on this self-assembly behavior, a novel composite was prepared from t-LNT and tetraphenylethylene (TPE) by entrapping TPE aggregates into the meshes of t-LNT fishnets. The as-prepared t-LNT/TPE composite largely enhanced the blue fluorescence of TPE in water, exhibiting stable optical property and good biocompatibility, and t-LNT is expected to show great potential as a carrier of hydrophobic molecules for biomedical application. (c) 2017 Elsevier Ltd. All rights reserved.
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