A Low-Cost Time-Correlated Single Photon Counting System for Multiview Time-Domain Diffuse Optical Tomography

Diffuse optical tomography resorting to time-domain measurements (TD-DOT) provides informationrich data that have not yet been fully exploited for image reconstruction, notably to increase imaging spatial resolution. Current TD-DOT scanners suffer from a very low sensitivity owing to their small number of detection channels. This leads to excessively long acquisition times for in vivo imaging. To obtain a higher number of detection channels, thus increasing detection density, a low-cost time-correlated single photon counting (TCSPC) system dedicated to TD-DOT was designed, resorting solely to off-the-shelf electronic components to reduce costs, in distinction to custom application-specific integrated circuit solutions. The system features four input channels, each of them including a leading-edge discriminator for direct interfacing with off-the-shelf photodetector modules and a programmable delay line to compensate for undesired propagation delays, thus also avoiding manual adjustment of cable lengths. The system supports a large number of TCSPC channels using a daisy-chain configuration through an onboard Ethernet switch. It also features a 13.02 ps bin width with a 12.5 ns dynamic range. Results show excellent linearity, with a sDNL of 1.7% least significant bit (LSB), peak differential nonlinearity of 5% LSB, and peak integral nonlinearity of 10% LSB and an average accuracy of 19 ps full-width at half-maximum (FWHM) throughout two separate four-channel systems. The system was tested in a TD-DOT acquisition setup, and 37 ps FWHM instrument response functions were obtained using a single-photon avalanche diode (SPAD) detector. Diffuse intrinsic measurements were also acquired and compared with a reference TCSPC system showing similar results.