Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 56, Issue 43, Pages 13426-13430Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201706724
Keywords
carbon dioxide; carboxylation; nickel catalysis; photocatalysis; visible light
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Funding
- German Science Foundation (DFG) [GRK 1626]
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We report the efficient carboxylation of bromides and triflates with K2CO3 as the source of CO2 in the presence of an organic photocatalyst in combination with a nickel complex under visible light irradiation at room temperature. The reaction is compatible with a variety of functional groups and has been successfully applied to the synthesis and derivatization of biologically active molecules. In particular, the carboxylation of unactivated cyclic alkyl bromides proceeded well with our protocol, thus extending the scope of this transformation. Spectroscopic and spectroelectrochemical investigations indicated the generation of a Ni-0 species as a catalytic reactive intermediate.
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