Journal
INDONESIAN JOURNAL OF PHARMACY
Volume 28, Issue 2, Pages 82-90Publisher
UNIV GADJAH MADA, FAC FARMASI
DOI: 10.14499/indonesianjpharm28iss2pp82
Keywords
Myristica fatua Houtt.; resorcinol; malabaricone B; malabaricone C; cytotoxic
Categories
Funding
- Indonesian Institute of Sciences
Ask authors/readers for more resources
Myristica fatua Houtt. is one of the endemic plants growth in Wallace region. Isolation of the secondary metabolite compounds from the ethyl acetate fraction of the bark of Myristica fatua Houtt. has been done using some chromatography techniques afforded two resorcinol compounds, malabaricone C (1), and malabaricone B (2). The structures of 1-2 were determined using spectroscopic techniques, including mass spectrometry, 1D-NMR and 2D-NMR. Both compounds showed in vitro cytotoxic activity against the breast carcinoma cancer cell lines MCF-7 using alamar blue assay method, with IC50 of 2(.)38 and 0.71 mu g/mL, respectively.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available