Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 56, Issue 41, Pages 12624-12627Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201707304
Keywords
allylic alkylation; asymmetric catalysis; monoterpene indole alkaloids; stereodivergent cyclizations; total synthesis
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Funding
- NIH-NIGMS [R01GM080269]
- Amgen
- Gordon and Betty Moore Foundation
- Caltech Center for Catalysis and Chemical Synthesis
- Caltech
- NSF [DGE-1144469]
- Swiss National Science Foundation (SNSF) [P2EZP2_168798]
- Swiss National Science Foundation (SNF) [P2EZP2_168798] Funding Source: Swiss National Science Foundation (SNF)
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Enantioselective Pd-catalyzed allylic alkylations of dihydropyrido[1,2-a]indolone (DHPI) substrates were used to construct the C20-quaternary stereocenters of multiple monoterpene indole alkaloids. Stereodivergent Pictet-Spengler and Bischler-Napieralski cyclization/reduction cascades furnish the cis- and trans-fused azadecalin subunits present in Aspidosperma and Kopsia alkaloids, respectively, enroute to highly efficient syntheses of (+)-limaspermidine and (+)-kopsihainanine A.
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