Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 116, Issue -, Pages 63-72Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2016.08.002
Keywords
Placenta; Pregnancy; Transporters; Biotransformation
Categories
Funding
- Citizens United for Research in Epilepsy
- Saudi Arabian Cultural Mission
- Eunice Kennedy Shriver National Institute of Child Health and Human Development [R01HD083003, U54HD047891]
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The placenta serves as the interface between the maternal and fetal circulations and regulates the transfer of oxygen, nutrients, and waste products. When exogenous substances are present in the maternal bloodstream whether from environmental contact, occupational exposure, medication, or drug abuse the extent to which this exposure affects the fetus is determined by transport and biotransformation processes in the placental barrier. Advances in drug delivery strategies are expected to improve the treatment of maternal and fetal diseases encountered during pregnancy. (C) 2016 Elsevier B.V. All rights reserved.
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