Journal
BIOMEDICAL PHYSICS & ENGINEERING EXPRESS
Volume 3, Issue 3, Pages -Publisher
IOP PUBLISHING LTD
DOI: 10.1088/2057-1976/aa7001
Keywords
dual macro-nano porous scaffold; structured fibrillar collagen; compressive strength; bioactivity
Funding
- Andalusian Ministry of Economy, Science and Innovation [Proyecto Excelencia CTS-6681]
- CONACYT-Mexico
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The development of scaffolds mimicking native bone tissue composition and structure is a challenge in bone tissue engineering. 3D scaffolds with both an interconnected macropore structure and nanotextured surfaces are required. However, 3D scaffolds processed by microfabrication usually lack of nanotextured surface, while nanotextured materials generated by bottom-up nanofabrication are difficult to process conforming scaffolds having well interconnected microsized cavities. In this work, the processing of reticulated (macropore interconnected) structures using nanostructured precursors has been performed to improve the mechanical properties of the scaffolds. The application of a fibrillar collagen coating, using less than 1 wt% collagen per scaffold, has allow a significant increase of the compressive strength while preserving a high surface area and nanopore accessibility. Besides, the fibrillar nanostructured collagen coating promotes hydroxyapatite mineralization. Two different collagen-coating procedures are applied showing interesting differences in terms of mechanical performance.
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