Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 56, Issue 44, Pages 13805-13808Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201705122
Keywords
alkynes; aminosulfonylation; radical reactions; silver catalysis; stereoselectivity
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Funding
- NSFC [21522202, 21502017]
- EPSRC [EP/M019195/1]
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A silver-catalyzed intermolecular aminosulfonylation of terminal alkynes with sodium sulfinates and TMSN3 is reported. This three-component reaction proceeds through sequential hydroazidation of the terminal alkyne and addition of a sulfonyl radical to the resultant vinyl azide. The method enables the stereoselective synthesis of a wide range of beta-sulfonyl enamines without electron-withdrawing groups on the nitrogen atom. These enamines are found to be suitable for a variety of further transformations.
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