Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 56, Issue 44, Pages 13752-13756Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201708005
Keywords
controllable release; metal-organic frameworks; photodynamic therapy; selectivity; singlet oxygen
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Funding
- 973 Program [2013CB933800]
- National Natural Science Foundation of China [21390411, 21535004, 21675103, 21602126]
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Photodynamic therapy (PDT) has emerged as an important minimally invasive tumor treatment technology. The search for an effective photosensitizer to realize selective cancer treatment has become one of the major foci in recent developments of PDT technology. Controllable singlet-oxygen release based on specific cancer-associated events, as another major layer of selectivity mode, has attracted great attention in recent years. Here, for the first time, we demonstrated that a novel mixed-metal metal-organic framework nanoparticle (MOF NP) photosensitizer can be activated by a hydrogen sulfide (H2S) signaling molecule in a specific tumor micro-environment for PDT against cancer with controllable singlet-oxygen release in living cells. The effective removal of tumors in vivo further confirmed the satisfactory treatment effect of the MOF NP photosensitizer.
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