Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 56, Issue 44, Pages 13661-13665Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201706910
Keywords
cytoprotection; individual living cell manipulation; MnO2; nanozymes
Categories
Funding
- National Natural Science Foundation of China [21210002, 21431007, 21533008, 21403209]
- Jilin Province Science and Technology Development Plan Project [20160520129JH, 20170101184JC]
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A powerful individual living cell encapsulation strategy for long-term cytoprotection and manipulation is reported. It uses manganese dioxide (MnO2) nanozymes as intelligent shells. As expected, yeast cells can be directly coated with continuous MnO2 shells via bio-friendly Mn-based mineralization. Significantly, the durable nanozyme shells not only can enhance the cellular tolerance against severe physical stressors including dehydration and lytic enzyme, but also enable the survival of cells upon contact with high levels of toxic chemicals for prolonged periods. More importantly, these encased cells after shell removal via a facile biomolecule stimulus can fully resume growth and functions. This strategy is applicable to a broad range of living cells
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