Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 56, Issue 44, Pages 13612-13617Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201706522
Keywords
dendrimers; discrete oligomers; iterative growth; Michael-type additions; thiol-maleimide
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Funding
- National Nature Science Foundation of China [21674072, 21234005]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- Program of Innovative Research Team of Soochow University
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Orthogonal maleimide and thiol deprotections were combined with thiol-maleimide coupling to synthesize discrete oligomers/macromolecules on a gram scale with molecular weights up to 27.4 kDa (128mer, 7.9 g) using an iterative exponential growth strategy with a degree of polymerization (DP) of 2(n)-1. Using the same chemistry, a readable sequence-defined oligomer and a discrete cyclic topology were also created. Furthermore, uniform dendrons were fabricated using sequential growth (DP=2(n)-1) or double exponential dendrimer growth approaches (DP=2(2n)-1) with significantly accelerated growth rates. Aversatile, efficient, and metal-free method for construction of discrete oligomers with tailored structures and a high growth rate would greatly facilitate research into the structure-property relationships of sophisticated polymeric materials.
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