Journal
CHEMISTRY OF MATERIALS
Volume 29, Issue 20, Pages 8637-8652Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.chemmater.7b02441
Keywords
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Funding
- National Key R&D Program of China [2016YFA0203700]
- National Natural Science Foundation of China [51672303, 81471673, 81671699]
- Shanghai Hospital Development Center [SHDC12016233]
- Youth Innovation Promotion Association of the Chinese Academy of Sciences [2013169]
- CAST [2015QNRC001]
- Development Fund for Shanghai Talents
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The emerging of two-dimensional (2D) MXenes significantly broadens the family members and versatile applications of 2D materials, but the rational design of MXene-based composites and their specific applications in theranostic biomedicine are still challenging. In this work, we report, for the first time, on the elaborate design of the Ti3C2-based composite MXene (MnOx/Ti3C2) for highly efficient theranostic applications against cancer. These MnOx/Ti3C2 composite MXenes have been constructed by triggering a simple redox reaction to in situ grow small MnOx nanosheets on the surface of Ti3C2. These MnOx/Ti3C2 composite MXenes have been developed as multifunctional theranostic agents for efficient magnetic resonance (MR) and photoacoustic (PA) dual-modality imaging-guided photothermal therapy (PTT) against cancer. Especially, the decoration of the MnOx component onto MnOx/Ti3C2 realizes the unique tumor microenvironment-responsive T-1-weighted MR imaging of tumors, and the high photothermal-conversion performance not only endows the MnOx/Ti3C2 with desirable contrast-enhanced PA-imaging property but also realizes the highly efficient tumor ablation and tumor-growth suppression. The in vivo biocompatibility of these MnOx/Ti3C2-SP composite nanosheets has also been systematically evaluated and revealed. This work not only paves a new way for the multifunctionalization of 2D MXenes simply by integrating other functional components but also broadens their versatile applications in theranostic nanomedicine.
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