Journal
CANCER TREATMENT REVIEWS
Volume 60, Issue -, Pages 24-31Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ctrv.2017.08.004
Keywords
IL-8 (CXCL8); CXCR1/2; Pharmacodynamic biomarker; Myeloid-derived suppressor cells; Cancer therapeutic agents; Immunotherapy
Categories
Funding
- MICINN [SAF2011-22831, SAF2014-52361-R]
- Spanish Society of Clinical Oncology Fellowship
- Departamento de Salud del Gobierno de Navarra
- Redes tematicas de investigacion cooperativa RETICC
- European Commission VII Framework and Horizon program (AICR)
- European Commission VII Framework and Horizon program (PROCROP)
- Fundacion de la Asociacion Espaflola Contra el Cancer (AECC)
- Fundacion BBVA
Ask authors/readers for more resources
Interleukin-8 (CXCL8) was originally described as a chemokine whose main function is the attraction of a polymorphonuclear inflammatory leukocyte infiltrate acting on CXCR1/2. Recently, it has been found that tumors very frequently coopt the production of this chemokine, which in this malignant context exerts different pro-tumoral functions. Reportedly, these include angiogenesis, survival signaling for cancer stem cells and attraction of myeloid cells endowed with the ability to immunosuppress and locally provide growth factors. Given the fact that in cancer patients IL-8 is mainly produced by tumor cells themselves, its serum concentration has been shown to correlate with tumor burden. Thus, IL-8 serum concentrations have been shown to be useful as a pharmacodynamic biomarker to early detect response to immunotherapy. Finally, because of the roles that IL-8 plays in favoring tumor progression, several therapeutic strategies are being developed to interfere with its functions. Such interventions hold promise, especially for therapeutic combinations in the field of cancer immunotherapy. (C) 2017 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available