Journal
ANNALS OF HEPATOLOGY
Volume 16, Issue -, Pages S15-S20Publisher
ELSEVIER ESPANA
DOI: 10.5604/01.3001.0010.5494
Keywords
Metabolic regulators; Farnesoid X receptor (FXR); G protein-coupled receptor (TGR5/M-BAR); Fibroblast growth factor-19 (FGF19); Glucose homeostasis
Categories
Funding
- Clinic of Digestive Diseases and Obesity of Medica Sur Clinic Foundation
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Bile acids (BAs), the end products of cholesterol catabolism, are essential for the absorption of lipids and fat-soluble vitamins; but they have also emerged as novel signaling molecules that act as metabolic regulators. It has been well described that the enterohepatic circulation, a nuclear (FXR) and a cytoplasmic (TGR5/M-BAR) receptor aid in controlling hepatic bile acid synthesis. Modulating bile acid synthesis greatly impacts in metabolism, because these receptors also are implicated in glucose, lipid, and energy expenditure. Recent studies had revealed the way these receptors participate in regulating gluconeogenesis, peripheral insulin sensitivity, glycogen synthesis, glucagon like peptide 1 (GLP-1) and insulin secretion. Nowadays, it is demonstrated that enhancing bile acid signaling in the intestine contributes to the metabolic benefits of bile acid sequestrants and bariatric surgery on glucose homeostasis. This paper discusses the role of bile acid as regulators of glucose metabolism and their potential as therapeutic targets for diabetes.
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