Journal
BIOMACROMOLECULES
Volume 18, Issue 11, Pages 3834-3843Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.biomac.7b01210
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Funding
- Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan
- JSPS KAKENHI [25870078]
- Next-Generation World-Leading Researchers (NEXT Program) of MEXT
- Grants-in-Aid for Scientific Research [25870078] Funding Source: KAKEN
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We developed a biodegradable polycarbonate that demonstrates antithrombogenicity and vascular cell adhesion via organocatalytic ring-opening polymerization of a trimethylene carbonate (TMC) analogue bearing a methoxy group. The monoether-tagged polycarbonate demonstrates a platelet adhesion property that is 93 and 89% lower than those of poly(ethylene terephthalate) and polyTMC, respectively. In contrast, vascular cell adhesion properties of the polycarbonate are comparable to those controls, indicating a potential for selective cell adhesion properties. This difference in the cell adhesion property is well associated with surface hydration, which affects protein adsorption and denaturation. Fibrinogen is slightly denatured on the monoether-tagged polycarbonate, whereas fibronectin is highly activated to expose the RGD motif for favorable vascular cell adhesion. The surface hydration, mainly induced by the methoxy side chain, also contributes to slowing the enzymatic degradation. Consequently, the polycarbonate exhibits decent blood compatibility, vascular cell adhesion properties, and biodegradability, which is promising for applications in resorbable vascular grafts and stents.
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