Journal
CLINICAL NEUROPHYSIOLOGY
Volume 128, Issue 11, Pages 2268-2278Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.clinph.2017.08.023
Keywords
Transcranial magnetic stimulation; Continuous theta-burst stimulation; Plasticity; Interindividual variability; Cluster analysis; BDNF
Categories
Funding
- National Institutes of Health [NIH R01 MH100186]
- Harvard Catalyst | The Harvard Clinical and Translational Science Center (NCRR)
- Assimon Family
- NIH [R01 HD069776, R01 NS073601, R21 MH099196, R21 NS085491, R21 HD07616, R01 NS088583]
- Brainsway
- Sidney R. Baer, Jr. Foundation
- Massachusetts Life Sciences
- Takeda Medical
- Harvard Catalyst | The Harvard Clinical and Translational Science Center (NCATS NIH) [UL1 RR025758]
- Autism Speaks
- Natural Sciences and Engineering Research Council of Canada [NSERC PDF 454617]
- CRE Medical
- Nancy Lurie Marks Family Foundation
- Neuroelectrics
- Simons Foundation Autism Research Initiative (SFARI)
- Eisai
- Boston Children's Hospital Translational Research Program
- Sage Therapeutics
- Roche
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Objective: We used complete-linkage cluster analysis to identify healthy subpopulations with distinct responses to continuous theta-burst stimulation (cTBS).& para;& para;Methods: 21 healthy adults (age +/- SD, 36.9 +/- 15.2 years) underwent cTBS of left motor cortex. Natural log-transformed motor evoked potentials (LnMEPs) at 5-50 min post-cTBS (T5-T50) were calculated.& para;& para;Results: Two clusters were found; Group 1 (n = 12) that showed significant MEP facilitation at T15, T20, and T50 (p's < 0.006), and Group 2 (n = 9) that showed significant suppression at T5-T15 (p's < 0.022). LnMEPs at T10 and T40 were best predictors of, and together accounted for 80% of, cluster assignment.& para;& para;Results: In an exploratory analysis, we examined the roles of brain-derived neurotrophic factor (BDNF) and apolipoprotein E (APOE) polymorphisms in the cTBS response. Val66Met participants showed greater facilitation at T10 than Val66Val participants (p = 0.025). BDNF and cTBS intensity predicted 59% of interindividual variability in LnMEP at T10. APOE did not significantly affect LnMEPs at any time point (p's > 0.32).& para;& para;Conclusions: Data-driven cluster analysis can identify healthy subpopulations with distinct cTBS responses. T10 and T40 LnMEPs were best predictors of cluster assignment. T10 LnMEP was influenced by BDNF polymorphism and cTBS intensity.& para;& para;Significance: Healthy adults can be sorted into subpopulations with distinct cTBS responses that are influenced by genetics. (C) 2017 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
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