Journal
CELLULAR IMMUNOLOGY
Volume 321, Issue -, Pages 26-34Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.cellimm.2017.04.012
Keywords
T-bet; B cells; HIV; HCV; Humoral immunology
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Funding
- NIH [R01 AI 076066]
- VA Merit Review
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T-bet-expressing B cells, first identified as perpetuators of autoimmunity, were recently shown to be critical for murine antiviral responses. While their role in human viral infections remains unclear, B cells expressing T-bet or demonstrating a related phenotype have been described in individuals chronically infected with HIV or HCV, suggesting these cells represent a component of human antiviral responses. In this review, we discuss the induction of T-bet in B cells following both HIV and HCV infections, the factors driving T-bet(+) B cell expansions, Tbet's relationship to atypical memory B cells, and the consequences of T-bet induction. We propose potential antiviral roles for T-bet(+) B cells and discuss whether this population poses any utility to the HIV and HCV immune responses.
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