Journal
ADVANCED BIOSYSTEMS
Volume 1, Issue 11, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adbi.201700100
Keywords
drug delivery; fluorescence; photoacoustics; photodynamics; photothermal
Categories
Funding
- DFG
- BMBF
- excellence initiative of the German federal and state governments
- Hans Hermann Voss-Stiftung through the ERS (Exploratory Research Space @ RWTH Aachen)
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Conjugated polymer nanoparticles are highly fluorescent colloids with tunable emission colors ranging from the visible deep into the near infrared spectrum. Conjugated polymer nanoparticles are easy to prepare, tunable in their size, and virtually nonbleachable. Conjugated polymer particles can also be designed to give off heat upon irradiation. All these properties make conjugated polymer particles ideal materials for biomedical fluorescence and photoacoustic imaging as well as for theranostic applications. Here, different examples of surface functionalization to attach pathological homing devices, imaging modalities, as well as the emerging possibilities for therapeutic measures are discussed. Furthermore, clearance of the particles is considered, which is important to ultimately apply the materials for in vivo theranostics. Due to the conjugated backbone of the conjugated polymers, established degradation strategies, as known from hydrophilic nonconjugated polymer carriers, cannot be applied. Bioinspired strategies and potential pathways for degradation and clearance via structural changes upon triggers such as pH, oxidation, and temperature are also discussed in this progress report.
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