Journal
BIOMACROMOLECULES
Volume 18, Issue 11, Pages 3766-3775Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.biomac.7b01180
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Funding
- National Natural Science Foundation of China [51703185]
- Hi-Tech Research and Development 863 Program of China [2013AA102507]
- Fundamental Research Funds for the Central Universities [XDJK2017B041, XDJK2017C012]
- Social development project of Guangdong province [2017A020211015]
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Silver inlaid with gold nanoparticles (Au-Ag NPs) prepared by using egg white with an average sized of 10 nm and homogeneous dispersion were tested and presented red fluorescence. Au-Ag NPs were loaded into chitosan as wound dressing (CS-Au-Ag). CS-Au-Ag released silver ions faster, in higher amount, and in a more durable manner than chitosan dressing loaded with silver nanoparticles with the same silver content (CS-Ag), consequently, showing enhanced antibacterial activity. Cytotoxicity tests indicated that CS-Au-Ag showed low cytotoxicity to L929 cells similar to CS-Ag. These data suggest that cytotoxicity, which restricts further application of silver NPs, can be eliminated by decreasing the silver content. CS-Au-Ag presented rich and well-distributed pores, good mechanical properties, and enhanced swelling and retention properties, contributing to keeping the wound moist in the presence of residual egg white. Altogether, our results suggest that CS-Au-Ag greatly promoted wound healing compared to CS-Ag in vivo, demonstrating that CS-Au-Ag presents great potential for wound dressing, promoting wound healing.
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