Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
Volume 1862, Issue 11, Pages 1394-1403Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbalip.2016.10.008
Keywords
Glycolipid; ABC transport; Bacteria; Glycoconjugate; Export; Cell surface
Funding
- Canadian Institutes of Health Research [MOP-9623, MOP-62877]
- Canada Research Chair
- Natural Sciences and Engineering Research Council of Canada
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Glycoconjugates, molecules that contain sugar components, are major components of the cell envelopes of bacteria and cover much of their exposed surfaces. These molecules are involved in interactions with the surrounding environment and, in pathogens, play critical roles in the interplay with the host immune system. Despite the remarkable diversity in glycoconjugate structures, most are assembled by glycosyltransferases that act on lipid acceptors at the cytosolic membrane. The resulting glycolipids are then transported to the cell surface in processes that frequently begin with ATP-binding cassette transporters. This review summarizes current understanding of the structure and biosynthesis of glycolipid substrates and the structure and functions of their transporters. This article is part of a Special Issue entitled: Bacterial Lipids edited by Russell E. Bishop. (C) 2016 Elsevier B.V. All rights reserved.
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