Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
Volume 1864, Issue 11, Pages 2001-2014Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbamcr.2017.04.011
Keywords
Matrix metalloproteinases; Gelatinases; Thiiranes; ND-322; ND-336; MMP roles
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Funding
- American Diabetes Association [1-15-ACN-06]
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The focus of this article is to highlight novel inhibitors and current examples where the use of selective small molecule inhibitors has been critical in defining the roles of matrix metalloproteinases (MMPs) in disease. Selective small-molecule inhibitors are surgical chemical tools that can inhibit the targeted enzyme; they are the method of choice to ascertain the roles of MMPs and complement studies with knockout animals. This strategy can identify targets for therapeutic development as exemplified by the use of selective small-molecule MMP inhibitors in diabetic wound healing, spinal cord injury, stroke, traumatic brain injury, cancer metastasis, and viral infection. This article is part of a Special Issue entitled: Matrix Metalloproteinases edited by Rafael Fridman.
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