Journal
BIOCONJUGATE CHEMISTRY
Volume 28, Issue 11, Pages 2673-2686Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.bioconjchem.7b00368
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The escalation of multidrug-resistant pathogens has created a dire need to develop novel ways of addressing this global therapeutic challenge. Because of their antimicrobial activities, the combination of antimicrobial peptides (AMPs) and nanoparticles is a promising tool with which to kill drug resistant pathogens. In recent years, several studies using AMP-nanoparticle conjugates, especially metallic nanoparticles, as potential antimicrobial agents against drug-resistant pathogens have been published. Among these, antimicrobial-peptide conjugated gold nanoparticles (AMP-AuNPs) are particularly attractive because of the nontoxic nature of gold and the possibility of fine-tuning the AMP-NP conjugation chemistry. The following review discusses recent developments in the synthesis and antimicrobial activity studies of AMP-AuNPs. The used for functionalizing AuNPs with AMPs, and the antimicrobial activities classification of AMPs, their mechanisms of action, methods of the conjugates are discussed.
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