Journal
FEMS MICROBIOLOGY REVIEWS
Volume 41, Issue 6, Pages 751-780Publisher
OXFORD UNIV PRESS
DOI: 10.1093/femsre/fux044
Keywords
single cell analysis; heterogeneity; single cell dynamics; microfluidics; technical bias; lab-on-a-chip
Categories
Funding
- Graduate Cluster Industrial Biotechnology [CLIB 2021]
- BeBasic research program
- European Union (EFRE)
- German Federal Ministry for Economic Affairs and Energy
- Ministry of Innovation, Science, Research and Technology of North-Rhine Westphalia
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Microbial single cell analysis has led to discoveries that are beyond what can be resolved with population-based studies. It provides a pristine view of the mechanisms that organize cellular physiology, unbiased by population heterogeneity or uncontrollable environmental impacts. A holistic description of cellular functions at the single cell level requires analytical concepts beyond the miniaturization of existing technologies, defined but uncontrolled by the biological system itself. This review provides an overview of the latest advances in single cell technologies and demonstrates their potential. Opportunities and limitations of single cell microbiology are discussed using selected application-related examples.
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