Journal
ANESTHESIA AND ANALGESIA
Volume 125, Issue 5, Pages 1471-1474Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1213/ANE.0000000000002410
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- CSL Behring
- CSL Behring via Meridian HealthComms
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Prothrombin complex concentrates (PCCs) have been associated with a possible risk of thromboembolic complications, potentially attributable to an increased ratio of the plasma concentration of factor II (FII) to antithrombin (AT). We developed a mathematical model to examine the relationship between amounts of PCC or therapeutic plasma administered, and plasma levels of FII and AT. The model showed that PCC produces substantial increases in plasma levels of FII but only small changes in AT, increasing the FII: AT ratio. Therapeutic plasma was shown to have only modest effects on levels of FII or AT, unless high doses are used.
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