Journal
TRENDS IN CANCER
Volume 3, Issue 11, Pages 797-808Publisher
CELL PRESS
DOI: 10.1016/j.trecan.2017.09.006
Keywords
-
Categories
Funding
- ERC Advanced grant PATHFINDER [269019]
- Dutch Cancer Society KWO award [KUN2009-4402]
Ask authors/readers for more resources
Tumors can be divided into 'hot' (T cell inflamed) or 'cold' (T cell noninflamed) according to the presence of immune cells. In this review, we discuss variables that influence T cell migration into the tumor microenvironment. Chemokines can attract T cells to the tumor site and tumor intrinsic pathways can influence the composition of local chemokines. Tumor-induced vasculature can hamper T cell migration. Other immune cells and tumor-derived molecules can block T cell proliferation and survival. It is important to better understand these mechanisms in order to target them therapeutically. Enhancing T cell infiltration may increase response rates to immunotherapy and increase survival.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available