Journal
CELL CALCIUM
Volume 67, Issue -, Pages 105-115Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ceca.2017.05.002
Keywords
Immunity; Immune cells; signaling; Pro-inflammatory diseases; TRPM channel; alpha-Kinase; Calcium; Magnesium
Categories
Funding
- Deutsche Forschungsgemeinschaft [TRR 152/1]
- Marie-Curie Fellowship (REA)
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The immune system protects our body against foreign pathogens. However, if it overshoots or turns against itself, pro-inflammatory diseases, such as rheumatoid arthritis, inflammatory bowel disease, or diabetes develop. Ions, the most basic signaling molecules, shape intracellular signaling cascades resulting in immune cell activation and subsequent immune responses. Mutations in ion channels required for calcium signaling result in human immunodeficiencies and highlight those ion channels as valued targets for therapies against pro-inflammatory diseases. Signaling pathways regulated by melastatin-like transient receptor potential (TRPM) cation channels also play crucial roles in calcium signaling and leukocyte physiology, affecting phagocytosis, degranulation, chemokine and cytokine expression, chemotaxis and invasion, as well as lymphocyte development and proliferation. Therefore, this review discusses their regulation, possible interactions and whether they can be exploited as targets for therapeutic approaches to pro-inflammatory diseases. (C) 2017 Elsevier Ltd. All rights reserved.
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