Journal
ALZHEIMERS & DEMENTIA
Volume 11, Issue 7, Pages 823-831Publisher
WILEY
DOI: 10.1016/j.jalz.2015.05.004
Keywords
Alzheimer's disease; Subjective memory complaints; Amyloid cascade hypothesis
Categories
Funding
- Alzheimer's Disease Neuroimaging Initiative (ADNI) (National Institutes of Health) [U01 AG024904]
- DOD ADNI (Department of Defense) [W81XWH-12-2-0012]
- National Institute on Aging
- National Institute of Biomedical Imaging and Bioengineering
- Canadian Institutes of Health Research
- NIH [2P30CA093373-09, 2P30AG010129-21, 5U01AG024904-07, 5RC2AG036535-02, 5P30AG010129-23, R01AG047827, 2U01AG024904-06, 5R01HD042974-11, 5U54NS079202-02, 1U54HD079125-01]
- Alzheimer's Association
- Michael J. Fox Foundation
- W. Garfield Weston Foundation
- DOD [W81XWH-12-2-0012, W81XWH-13-1-0259]
- [3UL1RR024146-06S2]
- [5R01GM088336-03]
- [5R01AG012975-14]
- [5R25RR026008-03]
- [16BB-1600]
- [5U01AG10483-15]
- [1U01AG24904-01]
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Introduction: The Alzheimer's Disease Neuroimaging Initiative (ADNI) is a multisite study designed to characterize the trajectories of biomarkers across the aging process. We present ADNI Biostatistics Core analyses that integrate data over the length, breadth, and depth of ADNI. Methods: Relative progression of key imaging, fluid, and clinical measures was assessed. Individuals with subjective memory complaints (SMC) and early mild cognitive impairment (eMCI) were compared with normal controls (NC), MCI, and individuals with Alzheimer's disease. Amyloid imaging and magnetic resonance imaging (MRI) summaries were assessed as predictors of disease progression. Results: Relative progression of markers supports parts of the amyloid cascade hypothesis, although evidence of earlier occurrence of cognitive change exists. SMC are similar to NC, whereas eMCI fall between the cognitively normal and MCI groups. Amyloid leads to faster conversion and increased cognitive impairment. Discussion: Analyses support features of the amyloid hypothesis, but also illustrate the considerable heterogeneity in the aging process. (C) 2015 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
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