Journal
APPLIED RADIATION AND ISOTOPES
Volume 129, Issue -, Pages 108-116Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.apradiso.2017.07.062
Keywords
Radiophannaceuticals; Sc-47/46-HEDP; Sc-47/46-EDTMP; Biodistribution; Human dosimetry
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In this study labeling EDTMP (ethylenediamine tetra(methylene phosphonic acid)) and HEDP (Hydroxyethylidene-1, 1-Diphosphonic Acid) as the carrier ligands with Scandium-47 were investigated. The biokinetics of the bone seeking of labeled ligands with Scandium-47 were assessed by measuring the skeletal absorbed dose and then the mice data extrapolated to human absorbed dose and compared with the (186/188)Rhenium-HEDP, (153)Samarium-EDTMP dosimetry data estimated by other researchers. Because the availability of Sc-47 was limited we performed some preliminary studies using Sc-46.
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