Journal
ARCHIVES OF VIROLOGY
Volume 162, Issue 11, Pages 3305-3312Publisher
SPRINGER WIEN
DOI: 10.1007/s00705-017-3481-3
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Funding
- Science and Technology Support Program of Jiangsu Province for Emerging Infectious Diseases Control and Prevention [BE2015714]
- Key Medical Discipline of Jiangsu Province [ZDXKA2016008]
- National Natural Science Foundation of China [81501785]
- Natural Science Foundation of Jiangsu Province [BK20141030, BK20161583]
- 333 Projects of Jiangsu Province
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Metagenomic analysis through high-throughput sequencing is a tool for detecting both known and novel viruses. Using this technique, a novel circular single-stranded DNA (ssDNA) virus genome was discovered in respiratory secretions from a febrile traveler. The virus, named human respiratory-associated PSCV-5-like virus (HRAPLV), has a genome comprising 3,018 bases, with two major putative ORFs inversely encoding capsid (Cap) and replicase (Rep) protein and separated by two intergenic regions. One stem-loop structure was predicted in the larger intergenic region (LIR). The predicted amino acid sequences of the Cap and Rep proteins of HRAPLV showed highest identity to those of porcine stool-associated circular virus 5 isolate CP3 (PoSCV 5) (53.0% and 48.9%, respectively). The host tropism of the virus is unknown, and further study is warranted to determine whether this novel virus is associated with human disease.
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