Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 23, Issue 54, Pages 13314-13318Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201703316
Keywords
cyclic peptides; lactams; macrocycles; medium-sized rings; ring expansion
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Funding
- Leverhulme Trust [ECF-2015-013]
- University of York
- Science and Engineering Research Board, Department of Science & Technology, Government of India
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A successive ring-expansion protocol is reported that enables the controlled insertion of natural and non-natural amino acid fragments into lactams. Amino acids can be installed into macrocycles via an operationally simple and scalable iterative procedure, without the need for high dilution. This method is expected to be of broad utility, especially for the synthesis of medicinally important cyclic peptide mimetics.
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