Journal
ALZHEIMERS & DEMENTIA
Volume 11, Issue 5, Pages 485-493Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jalz.2014.04.518
Keywords
Alzheimer's disease; Mild cognitive impairment; Diffusion tensor imaging; Partial volume elimination; Free-water imaging
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Funding
- National Institutes of Health [R01MH074794, P41RR013218, P41EB015902]
- German Research Foundation (DFG) [ME 833/15-1]
- NARSAD Young Investigator grant from the Brain and Behavior Research Foundation
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Background: Brain atrophy in subjects with mild cognitive impairment (MCI) introduces partial volume effects, limiting the sensitivity of diffusion tensor imaging to white matter microstructural degeneration. Appropriate correction isolates microstructural effects in MCI that might be precursors of Alzheimer's disease (AD). Methods: Forty-eight participants (18 MCI, 15 AD, and 15 healthy controls) had magnetic resonance imaging scans and clinical evaluations at baseline and follow-up after 36 months. Ten MCI subjects were diagnosed with AD at follow-up and eight remained MCI. Free-water (FW) corrected measures on the white matter skeleton were compared between groups. Results: FW corrected radial diffusivity, but not uncorrected radial diffusivity, was increased across the brain of the converted group compared with the nonconverted group (P < .05). The extent of increases was similar to that found comparing AD with controls. Conclusion: Partial volume elimination reveals microstructural alterations preceding dementia. These alterations may prove to be an effective and feasible early biomarker of AD. (C) 2015 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
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