Journal
BLOOD REVIEWS
Volume 31, Issue 5, Pages 300-305Publisher
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.blre.2017.04.001
Keywords
Autophagy; LC3; Erythropoiesis; Red blood cell
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Funding
- Agencia Nacional de Promotion Cientifica y Tecnologica [PICT 2013-2335]
- CONICET (PIP)
- Universidad Nacional de Cuyo [SeCTyP 06/J367]
- PICT [2011-455]
- ECOS-Sud Programme (Programa de Cooperation Internacional Mincyt- ECOS)
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Autophagy is a well-known cellular process involved in many physiological and pathological processes. During erythropoiesis, autophagy plays an important role participating in the clearance of unnecessary organelles such as ribosomes and mitochondria (mitophagy) allowing the correct formation of mature red blood cells. The dysfunction of autophagy proteins hamper the correct erythroid maturation, leading to anemia, the release of immature cells from the bone marrow and other hematological abnormalities. Autophagy plays different roles depending on the type of pathology. In leukemia cells, it has been demonstrated that autophagy could be either detrimental, leading to an increase of the apoptosis rate, or protective, acting as a key process that augments proliferation and survival of cancer cells. Thus, understanding the relationship between autophagy and erythropoiesis opens new avenues for the discovery of biochemical and pharmacological targets and for the development of novel therapeutic approaches.
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