Journal
ADVANCED FUNCTIONAL MATERIALS
Volume 27, Issue 41, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201702732
Keywords
drug-release; hydrogels; nanomedicine; nanotechnology; origami
Categories
Funding
- Minerva Center for Biohybrid Complex Systems
- Council for Higher Education in Israel
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Stimuli-responsive, drug-loaded, DNA-based nano-and micro-capsules attract scientific interest as signal-triggered carriers for controlled drug release. The methods to construct the nano-/micro-capsules involve i) the layer-by-layer deposition of signal-reconfigurable DNA shells on drug-loaded microparticles acting as templates, followed by dissolution of the core templates; ii) the assembly of three-dimensional capsules composed of reconfigurable DNA origami units; and iii) the synthesis of stimuli-responsive drug-loaded capsules stabilized by DNA-polymer hydrogels. Triggers to unlock the nano-/micro-capsules include enzymes, pH, light, aptamer-ligand complexes, and redox agents. The capsules are loaded with fluorescent polymers, metal nanoparticles, proteins or semiconductor quantum dots as drug models, with anti-cancer drugs, e.g., doxorubicin, or with antibodies inhibiting cellular networks or enzymes over-expressed in cancer cells. The mechanisms for unlocking the nano-/micro-capsules and releasing the drugs are discussed, and the applications of the stimuli-responsive nano-/microcapsules as sense-and-treat systems are addressed. The scientific challenges and future perspectives of nano-capsules and micro-capsules in nanomedicine are highlighted.
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