Journal
BIOMARKER RESEARCH
Volume 5, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s40364-017-0106-7
Keywords
Tumor-associated macrophages (TAMs); Tumor microenvironment; Therapeutic target; Cancer treatment; Protumoral activities
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Funding
- National Natural Science Foundation of China [81171986, 81602024]
- State's Key Project of Research and Development Plan [2016YFC1303500]
- International Research Cooperation Grant from Science and Technology Department of Henan Province [162102410059]
- Ministry of Public Health [201501004]
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The fact that various immune cells, including macrophages, can be found in tumor tissues has long been known. With the introduction of concept that macrophages differentiate into a classically or alternatively activated phenotype, the role of tumor-associated macrophages (TAMs) is now beginning to be elucidated. TAMs act as protumoral macrophages, contributing to disease progression. As the relationship between TAMs and malignant tumors becomes clearer, TAMs are beginning to be seen as potential therapeutic targets in these cases. In this review, we will discuss how TAMs can be used as therapeutic targets of cancer in clinics.
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