Journal
VIRUS RESEARCH
Volume 237, Issue -, Pages 27-36Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.virusres.2017.05.008
Keywords
Enterovirus71; MicroRNA-21; MyD88; IRAK1; Type I IFN
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Funding
- Natural science research project in Education Department of Shaanxi Provincial Government [2013JK0773]
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Enterovirus71(EV71), the etiological agent of hand-foot-and-mouth disease, has increasingly become a public health challenge around the world. Type I interferons (IFNs) are an important family of cytokines that regulate innate and adaptive immune responses to pathogens. These pathways are tightly regulated by the host to prevent an inappropriate cellular response, but viruses can modulate these pathways to proliferate and spread. In this study, we demonstrated that EV71 evades the immune surveillance system to proliferate by activating microRNA-21. We demonstrated that EV71 infection upregulates miR-21, which in turn suppresses EV71-triggered type I IFN production, thus promoting EV71 replication. Furthermore, we demonstrated that miR-21 targets the myeloid differentiation factor 88(MyD88) and interleukin-1 receptor-associated kinase 1(IRAK1), which are involved in EV71-induced type I IFN production.
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