Journal
ANALYST
Volume 142, Issue 19, Pages 3699-3706Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7an00986k
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Funding
- National Natural Science Foundation of China [81273476]
- Innovative Research Team of the Ministry of Education and Program for Liaoning Innovative Research Team in University
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Rational engineering of native beta-CD as an ideal chiral selector for a definite analyte in capillary electrophoresis represents a challenge in separation science. Herein, a rational and systematic strategy that combines the de novo design and molecular modeling is firstly described to expedite the manipulation and selection of effective selector for enantioseparation in capillary electrophoresis. Using beta-adrenoreceptor agonists as model analytes, we demonstrate how this strategy efficiently improves the enantiorecognition in chiral discrimination sites of inclusion complexes. The evolved beta-CD derivative could be utilized as a chiral receptor to achieve the effective enantioseparation (Rs > 1.5) of racemic beta-adrenoreceptor agonists. We highlight a novel strategy for efficiently and rapidly manipulating native CD based on the characteristics of analyte so as to gain an excellent chiral selector.
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